Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers
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منابع مشابه
JPET #188433 Methamphetamine self-administration causes persistent striatal dopaminergic alterations and mitigates the deficits caused by a subsequent methamphetamine exposure
Preclinical studies have demonstrated that repeated methamphetamine (METH) injections (referred to herein as a “binge” treatment) cause persistent dopaminergic deficits. A few studies have also examined the persistent neurochemical impact of METH self-administration in rats, but with variable results. These latter studies are important because: 1) of their relevance to the study of METH abuse; ...
متن کاملMethamphetamine self-administration causes persistent striatal dopaminergic alterations and mitigates the deficits caused by a subsequent methamphetamine exposure.
Preclinical studies have demonstrated that repeated methamphetamine (METH) injections (referred to herein as a "binge" treatment) cause persistent dopaminergic deficits. A few studies have also examined the persistent neurochemical impact of METH self-administration in rats, but with variable results. These latter studies are important because: 1) they have relevance to the study of METH abuse;...
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It has been hypothesized that high-dose methamphetamine treatment rapidly redistributes cytoplasmic dopamine within nerve terminals, leading to intraneuronal reactive oxygen species formation and well characterized persistent dopamine deficits. We and others have reported that in addition to this persistent damage, methamphetamine treatment rapidly decreases vesicular dopamine uptake, as assess...
متن کاملReduction of striatal dopaminergic neurotransmission elevates striatal proenkephalin mRNA.
Dopamine-containing neurons have been shown to make direct contact with enkephalin-like immunoreactive neurons in the striatum of rat brain (Kubota et al., 1986). Chronic blockade of dopaminergic neurotransmission with the neuroleptic drug haloperidol has been reported to increase the striatal concentration of methionineenkephalin and proenkephalin m R N A (ENK mRNA) (Tang et al., 1983). We inv...
متن کاملMarkers Associated with Sex Differences in Methamphetamine-Induced Striatal Dopamine Neurotoxicity
Three different approaches were employed to assess various markers associated with sex differences in responses to methamphetamine (MA). Bioassay measures reveal that MA treatment results in significantly greater reductions in body weight and increases in body temperature in male mice. Protein and mRNA determinations show significant increases in Bcl-2 and PAI-1 in male mice, while females show...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2015
ISSN: 0022-3042
DOI: 10.1111/jnc.13391